Patricia Arquette in 'Holes'
Patricia Arquette (1968 - )
Granddaughter of Cliff "Charley Weaver" Arquette
Daughter of
Lewis Arquette
Sister of
Rosanna, Alexis, David & Richmond Arquette
Ex-Mrs.
Nicolas Cage
Mrs. Thomas Jane
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Inside Monkey Zetterland (1992) [Grace Zetterland]: Killed in an explosion while unwittingly carrying a bomb that a terrorist had planted in her bag. (It's been some time since I've seen this movie, so my memory is vague.)

Betrayed by Love (1994) [Deanna]: Strangled by Steven Weber on a hill. (Thanks to PortsGuy)

Infinity (1996) [Arline Greenbaum]: Dies of tuberculosis in the hospital, with Matthew Broderick sitting by her bedside. (Thanks to Eric)

The Secret Agent (1996) [Winnie]: Commits suicide (off-screen) by jumping overboard from a boat. (Thanks to Dani)

Lost Highway (1997) [Renee Madison/Alice Wakefield]: Playing a dual role, "Renee" is killed (off-screen) by Bill Pullman in her bedroom; we only see the blood-splattered walls afterwards. (The movie is highly open to interpretation; it's ambiguous whether her other character "Alice" is a different person, a different aspect of "Renee," or even whether she exists at all.)

Stigmata (1999) [Frankie Page]: Bleeds to death from her stigmata; she dies in Gabriel Byrne's arms. (This only occurs in the alternate ending on the DVD; the original theatrical ending has her surviving.) (Thanks to Alexis and Adriene)

Holes (2003) [Kissin' Kate Barlow]: Commits suicide by letting a venomous lizard bite her on the arm, after talking to Scott Plank and Allison Smith in the desert. (This occurs in the movie's Old-West flashback sequences.) (Thanks to Jude)

Medium: I Married a Mind Reader (2005) [Allison Dubois/Dorothy]: Decapitated by the guillotine in a dream sequence, seeing herself as Marie Antoinette; the scene ends with her waking up after the blade comes down. (She also has a psychic vision of herself reliving the life of another woman named "Dorothy," whose death occurs off-screen.) (Thanks to PortsGuy)

Medium: Too Close to Call (2005) [Allison Dubois]: Devoured by a "living" voting booth in a dream sequence, which likewise ends with her waking up just at the moment of her "death." (Thanks to PortsGuy)

Medium: Death Takes a Policy (2006) [Allison Dubois]: Appears as a dead body in a coffin when she witnesses her own funeral in a dream sequence. (Thanks to PortsGuy)